2009

Dating the emergence of pandemic influenza virus.

Smith GJD, Bahl J, Vijaykrishna D, Zhang JX, Poon LLM, Chen H, Webster RG, Peiris JSM & Guan Y (2009). PNAS   (106:11709-11712).

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic.

Smith GJD, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus O, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JSM, Guan Y & Rambaut A (2009). Nature   (459:1122-1125).

Gene flow and competitive exclusion of avian influenza A virus.

Bahl J, Vijaykrishna D, Holmes EC, Smith GJD & Guan Y (2009). Virology   (2009 Aug 1;390(2):289-97.).

Detection of diverse astroviruses from bats in China.

Zhu HC, Chu DKW, Liu W, Dong BQ, Zhang SY, Zhang JX, Li LF, Vijaykrishna D, Smith GJD, Chen H, Poon LLM, Peiris JSM, & Guan Y (2009). Journal of General Virology   (90:883-887).

Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008.

Smith GJD, Vijaykrishna D, Ellis TM, Dyrting KC, Leung YHC, Bahl J, Wong CW, Kai H, Chow MKW, Duan L, Chan ASL, Zhang LJ, Chen H, Luk GSM, Peiris JSM, & Guan Y (2009). Emerging Infectious Diseases   (15:402-407).

Analysis of H5N1 avian influenza infections from wild bird surveillance in Hong Kong from January 2006 to October 2007.

Ellis TM, Dyrting KC, Wong CW, Chadwick B, Chan C, Chiang M, Li C, Li P, Smith GJD, Guan Y & Peiris JSM (2009). Avian Pathology   (2009 Apr;38(2):107-19.).

2008

Detection and phylogenetic analysis of group 1 coronaviruses in South American bats.

Carrington CVF, Foster JE, Zhu HC, Zhang JX, Smith GJD, Thompson N, Auguste AJ, Ramkissoon V, Adesiyun AA & Guan Y (2008). Emerging Infectious Diseases (DOI: 10.3201/eid1412.080642).

The development and genetic diversity of H5N1 influenza virus in China, 1996-2006.

Duan L, Bahl J, Smith GJD, Wang J, Vijaykrishna D, Zhang LJ, Zhang JX, Li KS, Fan XH, Cheung CL, Huang K, Poon LLM, Shortridge KF, Webster RG, Peiris JSM, Chen H & Guan Y (2008). Virology (380: 243-254).

Evolutionary dynamics and emergence of panzootic H5N1 influenza viruses.

Vijaykrishna D, Bahl J, Riley S, Duan L, Zhang J, Chen H, Peiris JSM, Smith GJD & Guan Y (2008). PLoS Pathogens (4: e1000161).

Avian influenza A virus (H5N1) outbreaks, Kuwait, 2007.

Al-Azemi A, Bahl J, Al-Zenki S, Al-Shayji Y, Al-Ahmad S, Chen H, Guan Y, Peiris JSM, &Smith GJD (2008). Emerging Infectious Diseases 14: 958-961

Multiple lineages of influenza A (H5N1) viruses in Vietnam (2006-2007).

Nguyen TD, Nguyen TV, Vijaykrishna D, Guan Y, Peiris JSM, &Smith GJD (2008). Emerging Infectious Diseases 14: 632-636

Identification of the progenitors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern China.

Wang J, Vijaykrishna D, Duan L, Bahl J, Zhang JX, Webster RG, Peiris JSM, Chen H, Smith GJD, &Guan Y (2008). Journal of Virology 82: 3405-3414

2007

Establishment of influenza A virus (H6N1) in minor poultry in southern China.

Cheung CL, Vijaykrishna D, Smith GJD, Fan XH, Zhang JX, Bahl J, Duan L, Huang K, Tai H, Wang J, Poon LLM, Peiris JSM, Chen H, &Guan Y (2007). Journal of Virology 81: 10402-10412.

The genesis and evolution of H9N2 influenza viruses in poultry from southern China, 2000 to 2005.

Xu KM, Smith GJD, Bahl J, Duan L, Tai H, Vijaykrishna D, Wang J, Zhang JX, Li KS, Fan XH, Webster RG, Chen H, Peiris JSM &Guan Y (2007). Journal of Virology 81: 10389-10401.

Characterization of low pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 viruses.

Duan L, Campitelli L, Fan XH, Leung YHC, Vijaykrishna D, Zhang JX, Donatelli I, Delogu M, Li KS, Foni E, Chiapponi C, Wu WL, Kai H, Webster RG, Shortridge KF, Peiris JSM, Smith GJD, Chen H, & Guan Y (2007). Journal of Virology 81: 7529-7539.

Detection of a novel and highly divergent coronavirus from Asian leopard cat and Chinese ferret badger in southern China.

Dong BQ, Liu W, Fan XH, Vijaykrishna D, Tang XC, Gao F, Li LF, Li GJ, Zhang JX, Yang LQ, Poon LLM, Zhang SY, Peiris JSM, Smith GJD, Chen H &Guan Y (2007). Journal of Virology 81: 6920-6926.

Evolutionary insights into the ecology of Coronaviruses.

Vijaykrishna D, Smith GJD, Zhang JX, Peiris JSM, Chen H, & Guan Y (2007). Journal of Virology 81: 4012-4020.

Evolution and molecular epidemiology of H9N2 influenza A viruses from Quail in southern China, 2000 to 2005.

Xu KM, Li KS, Smith GJD, Li JW, Tai H, Zhang JX, Webster RG, Peiris, Chen H, & Guan Y (2007). Journal of Virology 81: 2635-2645.

2006

Emergence and predominance of an H5N1 influeza variant in China.

Smith GJ, Fan XH, Wang J, Li KS, Qin K, Zhang JX, Vijaykrishna D, Cheung CL, Huang K, Rayner JM, Peiris JS, Chen H, Webster RG & Guan Y (2006). PNAS 103: 16936-16941.

Prevalence and genetic diversity of coronaviruses from bats in southern China.

Tang XC, Zhang JX, Zhang SY, Wang P, Fan XH, Li LF, Li G, Dong BQ, Liu W, Cheung CL, Xu KM, Song WJ, Vijaykrishna D, Poon LLM, Peiris JSM, Smith GJD, Chen H, Guan Y. (2006). Journal of Virology 80: 7481-7490.

Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam.

Smith GJD, Naipospos TSP, Nguyen TD, de Jong MD, Vijaykrishna D, Usman TB, Hassan SS, Nguyen TV, Dao TV, Bui NA, Leung YHC, Cheung CL, Rayner JM, Zhang JX, Zhang LJ, Poon LLM, Li KS, Nguyen VC, Hien TT, Farrar J, Webster RG, Chen H, Peiris JSM, & Guan Y. (2006). Virology 350: 258-268.

Establishment of multiple sub-lineages of H5N1 influenza virus in Asia-implications for pandemic control.

Chen H, Smith GJD, Li KS, Wang J, Fan XF, Rayner JM, Zhang J, Vijaykrishna D, Guo CT, Cheung CL, Xu KM, Duan L, Huang K, Qin K, Leung YHC, Wu WH, Lu HR, Chen Y, Xiao NS, Naipospos TSP, Hassan SS, Nguyen TD, Zhang LJ, Yuen KY, Webster RG, Peiris JSM & Guan Y (2006). PNAS 103: 2845-2850.

2005

Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial apithelial cells.

Chan MCW, Cheung CY, Chui WH, Tsao SW, Nicholls JM, Chan Yo, Chan RWY, Long HT, Poon LLM, Guan Y & Peiris JSM (2005). Respiratory Research 6: 135.

Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection.

de Jong MD, Thanh TT, Khanh TT, Hien VM, Smith GJD, Chau NV, Cam BV, Qui PV, Ha DQ, Guan Y, Peiris JSM, Hien TT, Farrar J (2005). New England Journal of Medicine 353: 2667-2672.

Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003.

Butt KM, Smith GJD, Chen H, Zhang LJ, Leung YHC, Xu KM, Lim W, Webster RG, Yuen KY, Peiris JSM & Guan Y (2005). J Clin. Microbiology 43: 5760-5767.

Resistance to anti-influenza agents.

Guan Y & Chen H (2005). Lancet 366: 1139-40.

Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms.

Kan B, Wang M, Jing H, Xu H, Jiang X, Yan M, Liang W, Zheng H, Wan K, Liu Q, Cui B, Xu Y, Zhang E, Wang H, Ye J, Li G, Li M, Cui Z, Qi X, Chen K, Du L, Gao K, Zhao YT, Zou XZ, Feng YJ, Gao YF, Hai R, Yu D, Guan Y & Xu J (2005). J Virol. 79: 11892-900.

Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia.

Hulse-Post DJ, Sturm-Ramirez KM, Humberd J, Seiler P, Govorkova EA, Krauss S, Scholtissek C, Puthavathana P, Buranathai C, Nguyen TD, Long HT, Naipospos TS, Chen H, Ellis TM, Guan Y, Peiris JSM, Webster RG (2005). PNAS 102(30):10682-7.

Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia?

Sturm-Ramirez KM, Hulse-Post DJ, Govorkova EA, Humberd J, Seiler P, Puthavathana P, Buranathai C, Nguyen TD, Chaisingh A, Long HT, Naipospos TS, Chen H, Ellis TM, Guan Y, Peiris JS, Webster RG (2005). J Virol. 79:11269-79.

H5N1 virus outbreak in migratory waterfowl.

Chen H, Smith GJD, Zhang SY, Qin K, Wang J, Li KS, Webster RG, Peiris JSM & Guan Y (2005). Nature 436, 191-192.

Identification of a novel coronavirus in bats.

Poon LLM, Chu DKW, Chan KH, Wong OK, Ellis TM, Leung YHC, Lau SKP, Woo PCY, Suen KY, Yuen KY, Guan Y & Peiris JSM (2005). J Virol 79: 2001-2009.

2004

Severe acute respiratory syndrome.

Peiris JSM, Guan Y & Yuen KY (2004). Nature Medicine 10: S88-S97.

The aetiology, origins, and diagnosis of severe acute respiratory syndrome.

Poon LLM, Guan Y, Nicholls JM, Yuen KY & Peiris JSM (2004). Lancet Inf Dis 4: 663-671.

Confronting SARS: a view from Hong Kong.

Peiris JSM & Guan Y (2004). Philolophy Transaction of The Royal Society of London Series B-Biological Sciences 359: 1075-1079.

Genesis of a Dominant, Highly Pathogenic, Potentially Pandemic H5N1 Influenza Virus in Eastern Asia.

Li KS, Guan Y, Wang J, Smith GJD, Xu KM, Duan L, Rahaedjo AP, Puthavathana P, Buranthai C, Nguyen TD, Estoepangeste ATS, Chaisingh A, Auewarakul P, Long HT, Nahn NTH, Webby RJ, Poon LLM, Chen H, Shortridge KF, Yuen KY, Webster RG & Peiris JSM (2004). Nature 430: 209-213.

H5N1 influenza: a protean pandemic threat.

Guan Y, Poon LLM, Cheung CY, Ellis TM, Lim W, Lipatov AS, Chan KH, Sturm-Ramirez KM, Cheung CL, Leung YHC, Yuen KY, Webster RG & Peiris JSM (2004). PNAS 101: 8156-61.

Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines.

Webby RJ, Perez DR, Coleman JS, Guan Y, Knight JH, Govorkova EA, McClain-Moss LR, Peiris JS, Rehg JE, Tuomanen EI, Webster RG. (2004) Lancet 363: 1099-103.

Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome.

Guan Y, Peiris JS, Zheng B, Poon LL, Chan KH, Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang Y, Leung SW, Yuen KY, Leung FC. (2004). Lancet 363(9403): 99-104.

Re-emergence of fatal human influenza A subtype H5N1 disease.

Peiris JS, Yu WC, Leung CW, Cheung CY, Ng WF, Nicholls JM, Ng TK, Chan KH, Lai ST, Lim WL, Yuen KY & Guan Y (2004). Lancet 363(9409): 617-9.

Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia.

Woo PC, Lau SK, Tsoi HW, Chan KH, Wong BH, Che XY, Tam VK, Tam SC, Cheng VC, Hung IF, Wong SS, Zheng BJ, Guan Y, Yuen KY. (2004). Lancet. 363(9412): 841-5.

2003

Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China.

Guan Y, BJ Zheng, YQ He, XL Liu, ZX Zhuang, CL Cheung, SW Luo, PH Li, LJ Zhang, YJ Guan, KM Butt, KL Wong, KW Chan, W Lim, KF Shortridge, KY Yuen, JSM Peiris, LLM Poon. (2003). Science. 302(5643): 276-278.

Epidemiological and casue of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003.

Zhong NS, BJ Zheng, YM Li, LLM Poon, ZH Xie, PH Li, SY Tan, Q Chang, JP Xie, XQ Liu, J Xu, DX Li, KY Yuen, JSM Peiris & Guan Y. (2003). Lancet 362(9393): 1353-1358.

Lung Pathology of fatal severe acute respiratory syndrome.

Nicholls JM, Poon LLM, Lee KC, Ng WF, Lai ST, Leung CY, Chu CM, Hui PK, Mak KL, W Lim, KW Yan, KH Chan, NC Tsang, Guan Y, KY Yuen, JSM Peiris. (2003). Lancet 361(9371): 1773-1778.

Children with respiratory disease associated with metapneumovirus in Hong Kong.

Peiris JS, WH Tang, KH Chan, PL Khong, Guan Y, YL Lau, SS Chiu. (2003). Emerg Infect Dis 9(6): 628-33.

Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage.

Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LL, Guan Y, Rozanov M, Spaan WJ, Gorbalenya AE. (2003). J Mol. Biol. 331(5): 991-1004.

Coronavirus as a possible cause of severe acute respiratory syndrome.

Peiris JSM, ST Lai, LLM Poon, Guan Y, LYC Yam, W Lim, J Nicholls, WKS Yee, WW Yan, MT Cheung, VCC Cheng, KH Chan, DNC Tsang, RWH Yung, TK Ng, KY Yuen. (2003). Lancet 361 (9366): 1319-1325.